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Chronic alcohol intake activates intrahepatic macrophages, releasing inflammatory cytokines such as TNF- and IL-1, which promote liver inflammation, lipid accumulation, and fibrosis (Zhou et al., 2022

The ongoing development of next-generation senolytic peptides builds upon FOXO4-DRI's foundation while providing researchers with increasingly sophisticated tools for senescence research

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In comparison to control animals, HFD-fed mice demonstrated significantly lower GSH levels in the liver, whereas GSSG levels were significantly elevated (Fig

Together, these results point to an important role for ROS detoxification in Bd